American Christian Vande Velde is out of the Tour de France after being involved in a crash early in the seventh stage.
Organisers said Vande Velde withdrew following a mass pile-up after 11-km.
He was one of Garmin-Sharp's top contenders along with fellow American Andrew Talansky, Irishman Dan Martin and Canadian Ryder Hesjedal.
Vande Velde also sustained a shoulder problem after crashing on Wednesday.
Reuters